3-Fluoro-2,2-dimethylpropanoic acid

Name: 3-Fluoro-2,2-dimethylpropanoic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 64241-77-6
Cat. No. CS-W005928
Purity≥97%
MDL No.MFCD17677039

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-2,2-dimethylpropanoic acid|CS-W005928

Structure of 64241-77-6

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 64241-77-6
Cat. No. CS-W005928
Purity ≥97%
MDL No. MFCD17677039
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₉FO₂
Molecular Weight 120.12
Synonym(s) 3-Fluoro-2,2-dimethyl-propionic acid
SMILES CC(C)(CF)C(O)=O

Description

3-Fluoro-2,2-dimethylpropanoic acid features a sterically hindered quaternary carbon center flanked by a fluorine atom and two methyl groups, delivering enhanced metabolic stability. This electron-withdrawing fluorinated scaffold integrates readily into bioactive molecules, offering improved membrane permeability and resistance to enzymatic degradation in medicinal chemistry applications.

Application

3-Fluoro-2,2-dimethylpropanoic acid serves as a valuable building block in medicinal chemistry, offering a sterically hindered, fluorinated aliphatic carboxylic acid scaffold. Its stability and resistance to β-elimination facilitate reliable coupling reactions, enabling efficient incorporation into peptide and non-peptidic molecular architectures. The trifluoromethyl-like electronic profile, combined with enhanced metabolic stability, makes it particularly useful for optimizing pharmacokinetic properties in drug candidates.

Synthesis

Route1
- 1068560-15-5
- ~%
- In-stock
  
  64241-77-6
References
- Novartis AG Patent: US2009/163469 A1, 2009 ; Location in patent: Page/Page column 60 ; US 20090163469 A1
Route2
- In-stock
  
  14002-80-3
- ~%
- In-stock
  
  64241-77-6
References
- Bristol-Myers Squibb Company; Hewawasam, Piyasena; Kadow, John F.; Lopez, Omar D.; Meanwell, Nicholas A.; Tu, Yong; Wang, Alan Xiangdong; Xu, Ningning; Gupta, Samayamunthula Venkata Satya Arun Kumar; Srinivasu, Pothukanuri; Kumar, Indasi Gopi; Kumar, Ponugupati Suresh; Belema, Makonen; Fridell, Robert A.; Gao, Min; Lemm, Julie A.; O'Boyle, II, Donald R.; Sun, Jin-Hua; Wang, Chunfu; Wang, Ying-Kai Patent: US2013/183269 A1, 2013 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P304+P340-P331-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 37.3
LogP 1.0667
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Carboxylic Acid

Key Words

3-Fluoro-2,2-dimethylpropanoic acid sigma3-Fluoro-2,2-dimethylpropanoic acid manufacturer3-Fluoro-2,2-dimethylpropanoic acid price3-Fluoro-2,2-dimethylpropanoic acid structure3-Fluoro-2,2-dimethylpropanoic acid SDSbuy 3-Fluoro-2,2-dimethylpropanoic acid3-Fluoro-2,2-dimethylpropanoic acid supplier3-Fluoro-2,2-dimethylpropanoic acid uses3-Fluoro-2,2-dimethylpropanoic acid molecular weightprice of 3-Fluoro-2,2-dimethylpropanoic acid3-Fluoro-2,2-dimethylpropanoic acid chemical name formula of 3-Fluoro-2,2-dimethylpropanoic acid

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

3-Fluoro-2,2-dimethylpropanoic acid

CAS No. 64241-77-6

Recommended Products