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CS-W001157 4
Total: USD 88.00

4-Fluoro-7-azaindole

  • CAS No. 640735-23-5

  • Cat. No. CS-B0842
  • Purity≥96%
  • MDL No.MFCD08272231

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-7-azaindole|CS-B0842

Structure of 640735-23-5

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General Information

  • CAS No. 640735-23-5
  • Cat. No. CS-B0842
  • Purity ≥96%
  • MDL No. MFCD08272231
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FN₂
  • Molecular Weight 136.13
  • Synonym(s) 4-Fluoro-1H-pyrrolo[2,3-b]pyridine
  • SMILES FC1=CC=NC2=C1C=CN2

Description

4-Fluoro-7-azaindole delivers a robust, electron-deficient heterocyclic scaffold ideal for medicinal chemistry and materials science. This bench-stable compound features a fluorinated aryl ring paired with a nitrogen-rich core, enabling strong hydrogen bonding and enhanced solubility in polar solvents. Its unique electronic profile facilitates efficient coupling reactions and integration into complex molecular architectures.

Application

4-Fluoro-7-azaindole serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through established coupling and functionalization reactions. Its electron-deficient pyridine-like core enhances metabolic stability and modulates basicity, while the fluorine substituent facilitates targeted interactions in protein binding sites. Bench-stable and compatible with standard synthetic protocols, it functions effectively in cross-coupling, electrophilic substitution, and metal-mediated transformations.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.702
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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