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CS-W001157 4
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Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate

  • CAS No. 64067-99-8

  • Cat. No. CS-0041937
  • Purity≥98%
  • MDL No.MFCD03086230

*For research and further manufacturing use only, not for direct human use.

Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate|CS-0041937

Structure of 64067-99-8

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General Information

  • CAS No. 64067-99-8
  • Cat. No. CS-0041937
  • Purity ≥98%
  • MDL No. MFCD03086230
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈ClN₃O₂
  • Molecular Weight 225.63
  • Synonym(s) Ethyl 6-Chloroimidazo[1,2-β]pyridazine-2-carboxylate
  • SMILES O=C(C1=CN2N=C(Cl)C=CC2=N1)OCC

Description

Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate is a bench-stable heterocyclic ester featuring a chlorine-substituted imidazopyridazine core. This electron-deficient scaffold integrates readily into synthetic sequences requiring nitrogen-rich, planar frameworks. Its reactive chloro group enables palladium-catalyzed cross-coupling and nucleophilic substitution, facilitating rapid access to functionalized imidazopyridazine derivatives for medicinal chemistry applications.

Synthesis

  • Route1
    • In-stock
      3-Amino-6-chloropyridazine|CS-W019657
      5469-69-2
    • null|null
      70-23-5
    • ~34%
    • In-stock
      Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate|CS-0041937
      64067-99-8

    References

    • Luraschi; Arena; Sacchi; Laneri; Abignente; Avallone; D'Amico; Berrino; Rossi Farmaco, 1997 , vol. 52, # 4 p. 213 - 217

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   56.49
  • LogP   1.5594
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   2

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