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CS-W001157 4
Total: USD 88.00

3-(1,3-Dioxolan-2-yl)aniline

  • CAS No. 6398-87-4

  • Cat. No. CS-0156893
  • Purity≥95%
  • MDL No.MFCD00272236
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-(1,3-Dioxolan-2-yl)aniline|CS-0156893

Structure of 6398-87-4

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Description

3-(1,3-Dioxolan-2-yl)aniline features a protected hydroxyl-bearing dioxolane ring tethered to an aromatic amine, enabling stable storage and controlled release under acidic conditions. This masked phenol derivative integrates seamlessly into synthetic sequences requiring orthogonal functionality, offering enhanced handling without compromising reactivity in cross-coupling or cyclization workflows.

Application

3-(1,3-Dioxolan-2-yl)aniline serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized aromatic scaffolds. The 1,3-dioxolan-2-yl group acts as a stable, bench-compatible protecting group for aldehydes, readily cleaved under mild acidic conditions to reveal the corresponding aldehyde functionality. This enables downstream transformations such as reductive amination, coupling reactions, and heterocycle formation. Its compatibility with diverse reaction conditions and ease of purification make it particularly valuable in medicinal chemistry and process development workflows.

General Information

  • CAS No. 6398-87-4
  • Cat. No. CS-0156893
  • Purity ≥95%
  • MDL No. MFCD00272236
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₂
  • Molecular Weight 165.19
  • Synonym(s) M-AMINOBENZALDEHYDE ETHYLENE GLYCOL ACETAL
  • SMILES C1=CC(=CC(=C1)N)C2OCCO2

Computational Chemistry Data

  • TPSA   44.48
  • LogP   1.3142
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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