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Structure of 63972-18-9
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Diethyl 2-(3-cyanopropyl)malonate features a malonate core flanked by ethyl esters and a terminal nitrile group, enabling direct incorporation into heterocyclic scaffolds. This bifunctional reagent integrates readily under standard conditions, offering efficient access to nitrogen-containing ring systems via cyclization pathways.
Diethyl 2-(3-cyanopropyl)malonate serves as a versatile synthon in heterocyclic synthesis, enabling efficient construction of pyrrolidine and piperidine scaffolds via cyclization with amines. Its α,α-disubstituted malonate core exhibits excellent functional group tolerance, facilitating subsequent transformations such as hydrolysis, decarboxylation, and nucleophilic additions. The pendant nitrile group provides a handle for further derivatization, including reduction to primary amine or conversion to amidines. Bench-stable and readily purified by distillation or chromatography, it functions reliably in multi-step sequences common in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: