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6-Hydroxy-N,2-dimethylbenzofuran-3-carboxamide

  • CAS No. 638217-08-0

  • Cat. No. CS-0067399
  • Purity≥98%
  • MDL No.MFCD09836137

*For research and further manufacturing use only, not for direct human use.

6-Hydroxy-N,2-dimethylbenzofuran-3-carboxamide|CS-0067399

Structure of 638217-08-0

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General Information

  • CAS No. 638217-08-0
  • Cat. No. CS-0067399
  • Purity ≥98%
  • MDL No. MFCD09836137
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁NO₃
  • Molecular Weight 205.21
  • Synonym(s) 6-Hydroxy-N-methyl-2-methyl-1-benzofuran-3-carboxamide
  • SMILES O=C(C1=C(C)OC2=CC(O)=CC=C12)NC

Description

6-Hydroxy-N,2-dimethylbenzofuran-3-carboxamide features a hydroxyl group at the 6-position and a dimethyl substitution pattern that enhances solubility and metabolic stability. This scaffold integrates readily into bioactive molecule design, offering a polar yet lipophilic handle for medicinal chemistry optimization.

Application

6-Hydroxy-N,2-dimethylbenzofuran-3-carboxamide serves as a versatile building block for medicinal chemistry campaigns, enabling direct incorporation into bioactive heterocyclic scaffolds. Its hydroxyl and amide functionalities offer sites for derivatization via standard coupling, etherification, or acylation reactions. The molecule exhibits good bench stability and facilitates efficient purification, making it suitable for iterative synthesis workflows in API development and lead optimization.

Safety Information

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Computational Chemistry Data

  • TPSA   62.47
  • LogP   1.80642
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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