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CS-W001157 4
Total: USD 88.00

4-(Benzyloxy)aniline

  • CAS No. 6373-46-2

  • Cat. No. CS-W004935
  • Purity≥98%
  • MDL No.MFCD00025318

*For research and further manufacturing use only, not for direct human use.

4-(Benzyloxy)aniline|CS-W004935

Structure of 6373-46-2

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General Information

  • CAS No. 6373-46-2
  • Cat. No. CS-W004935
  • Purity ≥98%
  • MDL No. MFCD00025318
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₃NO
  • Molecular Weight 199.25
  • Synonym(s) 4-Benzyloxyaniline
  • SMILES NC1=CC=C(OCC2=CC=CC=C2)C=C1

Description

4-(Benzyloxy)aniline features a para-substituted aniline scaffold with a benzyl ether linkage, delivering enhanced solubility and stability in organic synthesis. This electron-rich aryl amine integrates readily into pharmaceutical intermediates and functional materials, offering predictable reactivity under standard conditions.

Application

4-(Benzyloxy)aniline serves as a versatile building block in medicinal chemistry and materials science, enabling direct access to functionalized arylamines through standard coupling and reduction protocols. The benzyloxy group provides orthogonal protection for phenolic hydroxyls, while the aniline moiety offers a reactive handle for amide formation, electrophilic substitution, or transition-metal-catalyzed cross-coupling. Its bench-stable nature and compatibility with common purification methods make it well-suited for multi-step synthesis workflows.

Synthesis

  • Route1

    References

    • Vernekar, Amit A.; Patil, Sagar; Bhat, Chinmay; Tilve, Santosh G. RSC Advances, 2013 , vol. 3, # 32 p. 13243 - 13250
  • Route2
    • null|null
      852668-28-1
    • ~43%
    • In-stock
      4-(Benzyloxy)aniline|CS-W004935
      6373-46-2

    References

    • AMBIT BIOSCIENCES CORPORATION Patent: WO2005/48948 A2, 2005 ; Location in patent: Page/Page column 168 ;
  • Route3
    • In-stock
      1-(Benzyloxy)-4-nitrobenzene|CS-0086361
      1145-76-2
    • ~90%
    • In-stock
      4-(Benzyloxy)aniline|CS-W004935
      6373-46-2
    • null|null
      123-30-8

    References

    • Journal of Organic Chemistry, , vol. 71, # 5 p. 2196 - 2199

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.8478
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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