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CS-W001157 4
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6-Chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine

  • CAS No. 63725-52-0

  • Cat. No. CS-0050233
  • Molecule weightNone
  • Purity≥97%
  • MDL No.MFCD22398833

*For research and further manufacturing use only, not for direct human use.

6-Chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine|CS-0050233

Structure of 63725-52-0

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General Information

  • CAS No. 63725-52-0
  • Cat. No. CS-0050233
  • Purity ≥97%
  • MDL No. MFCD22398833
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClN₃
  • Molecular Weight None
  • Synonym(s) None
  • SMILES CN1N=CC2=CC=C(Cl)N=C12

Description

6-Chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine is a heterocyclic scaffold featuring a chlorine atom at the 6-position and a methyl group at nitrogen-1, conferring enhanced electron-withdrawing character and metabolic stability. This configuration enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive molecules. The compound exhibits bench-stable handling characteristics and good solubility in common organic solvents, supporting its use in medicinal chemistry and process development workflows.

Application

6-Chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its chloro group facilitates nucleophilic substitution reactions, while the methylated pyrazolopyridine core offers enhanced metabolic stability and favorable binding interactions. The compound exhibits excellent bench stability and compatibility with standard coupling protocols, making it well-suited for parallel synthesis campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   30.71
  • LogP   1.6217
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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