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CS-W001157 4
Total: USD 88.00

Phenyl propionate

  • CAS No. 637-27-4

  • Cat. No. CS-0182542
  • Purity≥97%
  • MDL No.MFCD00053765

*For research and further manufacturing use only, not for direct human use.

Phenyl propionate|CS-0182542

Structure of 637-27-4

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General Information

  • CAS No. 637-27-4
  • Cat. No. CS-0182542
  • Purity ≥97%
  • MDL No. MFCD00053765
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₂
  • Molecular Weight None
  • Synonym(s) Propionic Acid Phenyl Ester
  • SMILES CCC(OC1=CC=CC=C1)=O

Description

Phenyl propionate is a phenolic ester featuring a propionate chain linked to a benzene ring. This structure imparts enhanced lipophilicity and metabolic stability compared to simpler esters. It serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty polymers. The compound exhibits good thermal stability and solubility in organic solvents, facilitating its use in multi-step reactions under standard conditions.

Application

Phenyl propionate serves as a stable, bench-ready ester intermediate enabling efficient introduction of phenyl and propionyl moieties in synthetic workflows. It functions reliably in nucleophilic acyl substitution reactions and provides access to aromatic ketones and pharmaceutical building blocks through controlled hydrolysis or reduction. Its compatibility with standard purification methods and tolerance to common functional groups make it a practical choice for medicinal chemistry and process development applications.

Synthesis

  • Route1
    • null|null
      79-03-8
    • null|null
      108-95-2
    • ~96%
    • In-stock
      Phenyl propionate|CS-0182542
      637-27-4

    References

    • Murashige, Ryo; Hayashi, Yuka; Ohmori, Syo; Torii, Ayuko; Aizu, Yoko; Muto, Yasuyuki; Murai, Yuta; Oda, Yuji; Hashimoto, Makoto Tetrahedron, 2011 , vol. 67, # 3 p. 641 - 649
  • Route2
    • null|null
      123-62-6
    • null|null
      108-95-2
    • ~97%
    • In-stock
      Phenyl propionate|CS-0182542
      637-27-4

    References

    • Dalpozzo, Renato; De Nino, Antonio; Maiuolo, Loredana; Oliverio, Manuela; Procopio, Antonio; Russo, Beatrice; Tocci, Amedeo Australian Journal of Chemistry, 2007 , vol. 60, # 1 p. 75 - 79
  • Route3

    References

    • Hirasawa, Satomi; Nagano, Hajime; Kameda, Yoko Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2207 - 2209

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.002
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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