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CS-W001157 4
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5-Amino-2-chlorophenol

  • CAS No. 6358-06-1

  • Cat. No. CS-W013317
  • Purity≥97%
  • MDL No.MFCD01707858

*For research and further manufacturing use only, not for direct human use.

5-Amino-2-chlorophenol|CS-W013317

Structure of 6358-06-1

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General Information

  • CAS No. 6358-06-1
  • Cat. No. CS-W013317
  • Purity ≥97%
  • MDL No. MFCD01707858
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO
  • Molecular Weight None
  • Synonym(s) 2-Chloro-5-aminophenol
  • SMILES OC1=CC(N)=CC=C1Cl

Description

5-Amino-2-chlorophenol delivers a bifunctional scaffold integrating an electron-rich amine and a reactive chloro substituent. This ortho-chlorinated phenol enables direct coupling in transition-metal-catalyzed cross-coupling reactions, serving as a key intermediate for pharmaceuticals and agrochemicals. The molecule exhibits enhanced solubility in polar solvents and stability under standard bench conditions.

Application

5-Amino-2-chlorophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling the construction of substituted heterocycles and aromatic scaffolds. Its ortho-chloro and amino functionalities offer complementary reactivity for palladium-catalyzed coupling reactions and electrophilic substitutions, with good bench stability and straightforward purification.

Synthesis

  • Route1

    References

    • Dhanak, Dashyant; Knight, Steven David Patent: US2003/100580 A1, 2003 ; US 20030100580 A1
  • Route2

    References

    • US3948596 A1, ;
  • Route3

    References

    • Environmental Toxicology and Chemistry, , vol. 20, # 7 p. 1381 - 1389

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.6278
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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