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CS-W001157 4
Total: USD 88.00

5-Chloro-2-thiopheneboronic Acid Pinacol Ester

  • CAS No. 635305-24-7

  • Cat. No. CS-0153849
  • Molecule weight244.55
  • Purity≥98%
  • MDL No.MFCD08063140

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-thiopheneboronic Acid Pinacol Ester|CS-0153849

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General Information

  • CAS No. 635305-24-7
  • Cat. No. CS-0153849
  • Purity ≥98%
  • MDL No. MFCD08063140
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄BClO₂S
  • Molecular Weight 244.55
  • Synonym(s) 2-(5-Chlorothiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • SMILES CC1(C)C(C)(C)OB(C2=CC=C(Cl)S2)O1

Description

5-Chloro-2-thiopheneboronic acid pinacol ester delivers a stable, bench-ready boronate handle for Suzuki-Miyaura cross-coupling. The thiophene core provides electron-deficient character, enhancing reactivity in palladium-catalyzed transformations. This pinacol ester resists hydrolysis and moisture, enabling reliable integration into complex molecular architectures under standard conditions.

Application

5-Chloro-2-thiopheneboronic acid pinacol ester serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. The pinacol boronate ester enhances shelf life and simplifies handling while maintaining high reactivity under standard catalytic conditions. Its thiophene core with ortho-chloro substitution enables sequential functionalization in medicinal chemistry and materials synthesis, offering excellent tolerance to diverse reaction partners and facilitating efficient purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.7007
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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