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CS-W001157 4
Total: USD 88.00

4,4-Diethoxybutylamine

  • CAS No. 6346-09-4

  • Cat. No. CS-W008785
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,4-Diethoxybutylamine|CS-W008785

Structure of 6346-09-4

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General Information

  • CAS No. 6346-09-4
  • Cat. No. CS-W008785
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₉NO₂
  • Molecular Weight 161.24
  • Synonym(s) 4,4-Diethoxy-1-butanamine; 4-Aminobutanal diethyl acetal; 4-Aminobutyraldehyde diethyl acetal; NSC 43756; 4-Aminobutyralodehyde diethyl ester
  • SMILES NCCCC(OCC)OCC

Description

4,4-Diethoxybutylamine features a flexible alkyl chain terminated by a primary amine, enabling efficient conjugation in bioconjugation workflows. The diethoxy substitution enhances solubility in polar organic solvents and provides stability under standard bench conditions. This functionality supports use in synthesizing tailored linkers for drug delivery systems and functionalized polymers.

Application

4,4-Diethoxybutylamine serves as a versatile bifunctional building block for the synthesis of bioactive heterocycles and peptide conjugates. Its primary amine functionality enables straightforward amidation and alkylation reactions, while the geminal diether moiety enhances solubility and stability under standard reaction conditions. The molecule functions effectively in nucleophilic substitution cascades and facilitates the construction of cyclic scaffolds via intramolecular cyclization, offering reliable access to complex architectures relevant to medicinal chemistry workflows.

Synthesis

  • Route1
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      18381-45-8
    • ~%
    • In-stock
      4,4-Diethoxybutylamine|CS-W008785
      6346-09-4

    References

    • Chemicke Listy, , vol. 46, p. 383 Chem.Abstr., , p. 4282
  • Route2
    • null|null
      1401564-75-7
    • ~%
    • In-stock
      4,4-Diethoxybutylamine|CS-W008785
      6346-09-4

    References

    • Journal of the American Chemical Society, , vol. 134, # 40 p. 16449 - 16451,3
  • Route3
    • 3-Butenal diethyl acetal|CS-0204763
      10602-36-5
    • ~%
    • In-stock
      4,4-Diethoxybutylamine|CS-W008785
      6346-09-4

    References

    • Journal of the American Chemical Society, , vol. 134, # 40 p. 16449 - 16451,3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H314-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   44.48
  • LogP   1.1244
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   7

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