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CS-W001157 4
Total: USD 88.00

3-(4-Bromobenzoyl)propionic acid

  • CAS No. 6340-79-0

  • Cat. No. CS-D1185
  • Purity≥97%
  • MDL No.MFCD00016563

*For research and further manufacturing use only, not for direct human use.

3-(4-Bromobenzoyl)propionic acid|CS-D1185

Structure of 6340-79-0

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General Information

  • CAS No. 6340-79-0
  • Cat. No. CS-D1185
  • Purity ≥97%
  • MDL No. MFCD00016563
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉BrO₃
  • Molecular Weight 257.08
  • Synonym(s) None
  • SMILES O=C(O)CCC(=O)C1=CC=C(Br)C=C1

Description

β-(4-Bromophenyl)propionic acid features a brominated aromatic ring linked to a propionic acid chain, enabling direct incorporation into pharmaceutical scaffolds. The para-bromine substituent enhances electrophilic reactivity and provides a handle for cross-coupling transformations. This bench-stable compound integrates readily into bioactive molecule design and serves as a key intermediate in medicinal chemistry campaigns targeting CNS and oncology therapeutics.

Application

β-(4-Bromophenyl)propionic acid serves as a versatile building block for pharmaceutical and agrochemical synthesis, enabling efficient incorporation of brominated aromatic moieties into target molecules. Its well-defined reactivity facilitates direct functionalization, coupling reactions, and downstream transformations under standard conditions. The molecule exhibits excellent bench stability, ease of purification, and compatibility with common protecting group strategies, making it a reliable intermediate in multi-step synthetic sequences.

Synthesis

  • Route1
    • In-stock
      Succinic anhydride|CS-0011581
      108-30-5
    • null|null
      108-86-1
    • ~95%
    • In-stock
      3-(4-Bromobenzoyl)propionic acid|CS-D1185
      6340-79-0

    References

    • Sonpatki; Herbert; Sandvoss; Seed Journal of Organic Chemistry, 2001 , vol. 66, # 22 p. 7283 - 7286
  • Route2

    References

    • Travis, Benjamin R.; Sivakumar, Meenakshi; Hollist, G. Olatunji; Borhan, Babak Organic Letters, 2003 , vol. 5, # 7 p. 1031 - 1034
  • Route3
    • In-stock
      5-(4-Bromophenyl)furan-2-carbaldehyde|CS-W009470
      20005-42-9
    • ~30%
    • null|null
      60112-48-3
    • In-stock
      3-(4-Bromobenzoyl)propionic acid|CS-D1185
      6340-79-0

    References

    • Organic Letters, , vol. 5, # 7 p. 1031 - 1034

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.37
  • LogP   2.4966
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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