5-Bromo-2-chloro-4-methylpyrimidine

Name: 5-Bromo-2-chloro-4-methylpyrimidine
Brand: ChemScene
Availability: InStock
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CAS No. 633328-95-7
Cat. No. CS-D1624
Purity≥97%
MDL No.MFCD13193654

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Bromo-2-chloro-4-methylpyrimidine|CS-D1624

Structure of 633328-95-7

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General Information

CAS No. 633328-95-7
Cat. No. CS-D1624
Purity ≥97%
MDL No. MFCD13193654
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄BrClN₂
Molecular Weight 207.46
Synonym(s) None
SMILES CC1=NC(Cl)=NC=C1Br

Description

5-Bromo-2-chloro-4-methylpyrimidine serves as a key heterocyclic building block for medicinal chemistry and agrochemical synthesis. The molecule features orthogonal halogen substituents at C5 (bromine) and C2 (chlorine), enabling sequential cross-coupling reactions. The methyl group at C4 enhances electronic modulation and improves solubility in organic media. This compound exhibits bench-stable handling properties and integrates readily into complex molecular architectures under standard coupling conditions.

Application

5-Bromo-2-chloro-4-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through palladium-catalyzed cross-coupling reactions. Its orthogonal halogen reactivity—bromine at C5 and chlorine at C2—facilitates sequential functionalization, while the methyl group at C4 enhances metabolic stability. The compound exhibits excellent bench stability, ease of purification, and broad compatibility with standard synthetic protocols, making it well-suited for both small-molecule discovery and process-scale applications.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 2.20092
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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5-Bromo-2-chloro-4-methylpyrimidine

CAS No. 633328-95-7

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