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Structure of 633-12-5
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2,4,6-Tribromobenzoic acid features three bromine atoms positioned at the 2, 4, and 6 ring sites, creating a highly electron-deficient aromatic core. This configuration enhances reactivity in electrophilic substitution and facilitates direct coupling in cross-coupling protocols. The carboxylic acid group enables salt formation and conjugation with amines or alcohols. Bench-stable and moisture-tolerant, it serves as a robust building block for functionalized aryl scaffolds in medicinal chemistry and materials science.
2,4,6-Tribromobenzoic acid serves as a versatile building block for brominated aromatic scaffolds, enabling efficient late-stage functionalization in medicinal chemistry and materials synthesis. Its three strategically positioned bromine atoms facilitate selective cross-coupling reactions, including Suzuki-Miyaura and Stille couplings, with high regiocontrol. The carboxylic acid group provides a handle for derivatization via amide formation or esterification, while the compound exhibits good bench stability and ease of purification, making it suitable for scalable applications in API development and advanced organic synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: