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CS-W001157 4
Total: USD 88.00

2-(4-Phenoxyphenyl)acetic acid

  • CAS No. 6328-74-1

  • Cat. No. CS-W010407
  • Purity≥97%
  • MDL No.MFCD00079779

*For research and further manufacturing use only, not for direct human use.

2-(4-Phenoxyphenyl)acetic acid|CS-W010407

Structure of 6328-74-1

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General Information

  • CAS No. 6328-74-1
  • Cat. No. CS-W010407
  • Purity ≥97%
  • MDL No. MFCD00079779
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₂O₃
  • Molecular Weight None
  • Synonym(s) benzeneacetic acid, 4-phenoxy-
  • SMILES O=C(O)CC1=CC=C(OC2=CC=CC=C2)C=C1

Description

2-(4-Phenoxyphenyl)acetic acid features a conjugated aryl ether linkage flanked by a carboxylic acid group, enabling robust integration into bioactive scaffolds. The phenoxy bridge enhances lipophilicity and metabolic stability, while the terminal acetic acid offers direct derivatization potential for amides, esters, or salt formation under standard conditions. This structure supports applications in medicinal chemistry and materials science where controlled polarity and structural rigidity are required.

Application

2-(4-Phenoxyphenyl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard functional group transformations. Its rigid biphenyl-like architecture provides structural stability and enhances target binding affinity. The carboxylic acid functionality facilitates derivatization via esterification, amidation, or coupling reactions, while the phenoxy substituent offers favorable lipophilicity and metabolic resistance. Bench-stable and readily purified by recrystallization, it functions reliably in multistep syntheses and scale-up processes.

Synthesis

  • Route1
    • null|null
      4664-61-3
    • ~91%
    • In-stock
      2-(4-Phenoxyphenyl)acetic acid|CS-W010407
      6328-74-1

    References

    • Takeda Pharmaceutical Company Limited Patent: EP1849465 A1, 2007 ; Location in patent: Page/Page column 139 ;
  • Route2
    • null|null
      114246-13-8
    • ~%
    • In-stock
      2-(4-Phenoxyphenyl)acetic acid|CS-W010407
      6328-74-1

    References

    • Rend. Ist. super. Sanita, , vol. 15, p. 1041,1048
  • Route3
    • null|null
      1255911-44-4
    • ~67%
    • null|null
      1255911-55-7
    • In-stock
      2-(4-Phenoxyphenyl)acetic acid|CS-W010407
      6328-74-1

    References

    • Tetrahedron Letters, , vol. 51, # 46 p. 6045 - 6048

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H317-H318-H410
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   3.106
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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