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CS-W001157 4
Total: USD 88.00

H-Asp(Obzl)-OBzl.HCl

  • CAS No. 6327-59-9

  • Cat. No. CS-0156258
  • Purity≥97%
  • MDL No.MFCD01075101

*For research and further manufacturing use only, not for direct human use.

H-Asp(Obzl)-OBzl.HCl|CS-0156258

Structure of 6327-59-9

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General Information

  • CAS No. 6327-59-9
  • Cat. No. CS-0156258
  • Purity ≥97%
  • MDL No. MFCD01075101
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₀ClNO₄
  • Molecular Weight 349.81
  • Synonym(s) H-Asp(OBzl)-Obzl.HCL
  • SMILES C1=CC=C(C=C1)COC(=O)C[C@@H](C(=O)OCC2=CC=CC=C2)N.Cl

Description

H-Tyr-OBzl·HCl features a protected tyrosine residue with a benzyl ester group, offering enhanced stability and ease of handling in peptide synthesis. This bench-stable derivative integrates seamlessly into automated workflows and supports efficient coupling reactions under standard conditions.

Application

H-Tyr-OBzl·HCl serves as a well-established building block for peptide synthesis, offering a protected tyrosine residue with orthogonal handling of the phenolic hydroxyl group. The benzyl ester (OBzl) protection ensures stability during standard coupling protocols and facilitates selective deprotection under mild hydrogenolysis conditions. Its crystalline form and high purity enable reliable handling and reproducible yields in multi-step synthetic sequences, making it a practical choice for medicinal chemistry and peptide library development.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry, , vol. 18, # 17 p. 6220 - 6229
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 58, # 9 p. 2369 - 2376
  • Route3
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    • In-stock
      H-Asp(Obzl)-OBzl.HCl|CS-0156258
      6327-59-9

    References

    • Journal of Organic Chemistry, , vol. 58, # 9 p. 2369 - 2376

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   78.62
  • LogP   2.6124
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   7

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