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CS-W001157 4
Total: USD 88.00

Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate

  • CAS No. 632-93-9

  • Cat. No. CS-0067585
  • Purity≥98%
  • MDL No.MFCD00005950

*For research and further manufacturing use only, not for direct human use.

Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate|CS-0067585

Structure of 632-93-9

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General Information

  • CAS No. 632-93-9
  • Cat. No. CS-0067585
  • Purity ≥98%
  • MDL No. MFCD00005950
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₁NO₄
  • Molecular Weight 267.32
  • Synonym(s) None
  • SMILES CC1C(C(OCC)=O)=C(NC(C)=C1C(OCC)=O)C

Description

Inhibiting ferrochelatase-mediated iron insertion, Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (CAS 632-93-9) disrupts heme biosynthesis and triggers Mallory-Denk body formation in murine hepatocytes, modeling iron overload pathologies.

Application

Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (CAS 632-93-9) induces Mallory-Denk body formation in murine hepatocytes through targeted metabolic disruption. This compound triggers hepatic protein aggregation. Researchers use it to model drug-induced liver injury and study cytoplasmic inclusion dynamics in vivo.

Synthesis

  • Route1
    • In-stock
      Ethyl acetoacetate|CS-0016216
      141-97-9
    • null|null
      75-07-0
    • ~93%
    • In-stock
      Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate|CS-0067585
      632-93-9

    References

    • Kumar, Atul; Maurya, Ram Awatar Synlett, 2008 , # 6 p. 883 - 885
  • Route2
    • null|null
      50-00-0
    • In-stock
      Ethyl acetoacetate|CS-0016216
      141-97-9
    • ~88%
    • In-stock
      Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate|CS-0067585
      632-93-9

    References

    • Zhang, Dong; Wu, Li-Zhu; Zhou, Li; Han, Xue; Yang, Qing-Zheng; Zhang, Li-Ping; Tung, Chen-Ho Journal of the American Chemical Society, 2004 , vol. 126, # 11 p. 3440 - 3441
  • Route3

    References

    • Lee, Jung Hwan Tetrahedron Letters, 2005 , vol. 46, # 43 p. 7329 - 7330

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.63
  • LogP   1.8999
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   4

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