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CS-W001157 4
Total: USD 88.00

2,3-Dimethylthiophene

  • CAS No. 632-16-6

  • Cat. No. CS-W011263
  • Purity≥98%
  • MDL No.MFCD00130081

*For research and further manufacturing use only, not for direct human use.

2,3-Dimethylthiophene|CS-W011263

Structure of 632-16-6

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General Information

  • CAS No. 632-16-6
  • Cat. No. CS-W011263
  • Purity ≥98%
  • MDL No. MFCD00130081
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈S
  • Molecular Weight 112.19
  • Synonym(s) 2,3-Dimethyl-thiophen
  • SMILES CC1=C(C)SC=C1

Description

2,3-Dimethylthiophene is a bench-stable, electron-rich heterocycle featuring two methyl groups at the 2- and 3-positions of the thiophene ring. This substitution pattern enhances stability while maintaining reactivity in transition metal-catalyzed coupling processes. The molecule serves as a valuable scaffold in organic synthesis and materials science due to its favorable electronic profile and resistance to oxidation under standard conditions.

Application

2,3-Dimethylthiophene serves as a versatile heterocyclic building block in synthetic organic chemistry, offering enhanced stability and defined regiochemistry for transition-metal-catalyzed couplings. Its methyl substituents provide steric and electronic modulation, facilitating functionalization at the 2- and 3-positions while maintaining compatibility with standard cross-coupling protocols. The compound functions reliably in the construction of complex thiophene-based scaffolds relevant to materials science and medicinal chemistry.

Synthesis

  • Route1

    References

    • American Home Products Corporation Patent: US6251936 B1, 2001 ;
  • Route2
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      260543-59-7
    • ~%
    • In-stock
      2,3-Dimethylthiophene|CS-W011263
      632-16-6

    References

    • Organic Letters, , vol. 2, # 3 p. 351 - 352
  • Route3
    • (Z)-3-Methylpent-2-en-4-yn-1-ol|CS-W021187
      6153-05-5
    • ~%
    • In-stock
      2,3-Dimethylthiophene|CS-W011263
      632-16-6

    References

    • Organic Letters, , vol. 2, # 3 p. 351 - 352

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅱ
Hazard Statements : H225-H302-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.36494
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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