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Benzo[b]thiophen-2-ylmethanamine

  • CAS No. 6314-43-8

  • Cat. No. CS-0187843
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Benzo[b]thiophen-2-ylmethanamine|CS-0187843

Structure of 6314-43-8

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General Information

  • CAS No. 6314-43-8
  • Cat. No. CS-0187843
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NS
  • Molecular Weight 163.24
  • Synonym(s) 1-(1-benzothiophen-2-yl)methanamine
  • SMILES C1=CC=C2C(=C1)C=C(CN)S2

Description

Benzo[b]thiophen-2-ylmethanamine features a fused benzothiophene scaffold with a primary amine handle, enabling direct incorporation into bioactive molecules. The arylamine moiety exhibits enhanced solubility and stability under standard conditions, facilitating use in medicinal chemistry and materials synthesis.

Application

Benzo[b]thiophen-2-ylmethanamine serves as a versatile building block for the synthesis of biologically active heterocycles, particularly in medicinal chemistry and agrochemical research. Its aromatic thiophene core imparts metabolic stability and favorable lipophilicity, while the primary amine functionality enables straightforward derivatization via alkylation, acylation, or coupling reactions. The compound exhibits good bench stability and is compatible with standard purification methods, facilitating integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 74, p. 664
  • Route2

    References

    • Synthetic Communications, , vol. 25, # 17 p. 2631 - 2637

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.36
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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