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CS-W001157 4
Total: USD 88.00

1-(Pyridin-3-yl)propan-2-one

  • CAS No. 6302-03-0

  • Cat. No. CS-0005378
  • Purity≥95%
  • MDL No.MFCD08457626

*For research and further manufacturing use only, not for direct human use.

1-(Pyridin-3-yl)propan-2-one|CS-0005378

Structure of 6302-03-0

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General Information

  • CAS No. 6302-03-0
  • Cat. No. CS-0005378
  • Purity ≥95%
  • MDL No. MFCD08457626
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO
  • Molecular Weight 135.16
  • Synonym(s) 1-(pyridin-3-yl)acetone
  • SMILES O=C(C)CC1=CC=CN=C1

Description

1-(Pyridin-3-yl)propan-2-one features a pyridine ring directly conjugated to a ketone-bearing propyl side chain, enabling its use in transition metal-catalyzed couplings and as a building block for bioactive heterocycles. The electron-deficient pyridine moiety enhances reactivity in nucleophilic additions, while the ketone group provides a handle for further functionalization. This compound exhibits bench-stable handling characteristics and good solubility in common organic solvents.

Application

1-(Pyridin-3-yl)propan-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through functionalization at the ketone and pyridine moieties. Its bench-stable nature and compatibility with common coupling and reduction protocols facilitate straightforward incorporation into complex molecular architectures.

Synthesis

  • Route1
    • N-methoxy-N-methyl-2-(pyridin-3-yl)acetamide|CS-0449949
      217316-41-1
    • null|null
      75-16-1
    • ~94%
    • In-stock
      1-(Pyridin-3-yl)propan-2-one|CS-0005378
      6302-03-0

    References

    • Hay, Michael P.; Turcotte, Sandra; Flanagan, Jack U.; Bonnet, Muriel; Chan, Denise A.; Sutphin, Patrick D.; Nguyen, Phuong; Giaccia, Amato J.; Denny, William A. Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 787 - 797
  • Route2
    • In-stock
      3-Chloropyridine|CS-W011253
      626-60-8
    • null|null
      67-64-1
    • ~75%
    • In-stock
      1-(Pyridin-3-yl)propan-2-one|CS-0005378
      6302-03-0

    References

    • Li, Pengbin; Lue, Bo; Fu, Chunling; Ma, Shengming Advanced Synthesis and Catalysis, 2013 , vol. 355, # 7 p. 1255 - 1259
  • Route3
    • 3-Oxo-2-(pyridin-3-yl)butanenitrile|CS-0973809
      90417-12-2
    • ~%
    • In-stock
      1-(Pyridin-3-yl)propan-2-one|CS-0005378
      6302-03-0

    References

    • Journal of the American Chemical Society, , vol. 72, p. 1988

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.2131
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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