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CS-W001157 4
Total: USD 88.00

Ethyl 2-ethoxybenzoate

  • CAS No. 6290-24-0

  • Cat. No. CS-0151456
  • Purity≥95%
  • MDL No.MFCD00142907

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-ethoxybenzoate|CS-0151456

Structure of 6290-24-0

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General Information

  • CAS No. 6290-24-0
  • Cat. No. CS-0151456
  • Purity ≥95%
  • MDL No. MFCD00142907
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄O₃
  • Molecular Weight 194.23
  • Synonym(s) propyl phenoxyacetate
  • SMILES CCOC1=CC=CC=C1C(=O)OCC

Description

Ethyl 2-ethoxybenzoate features a benzoate core with an ethoxy group at the ortho position, delivering enhanced solubility in organic solvents and stability under standard bench conditions. This ester integrates readily into synthetic sequences requiring ortho-substituted aromatic intermediates.

Application

Ethyl 2-ethoxybenzoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted benzoic acid derivatives and heterocyclic scaffolds. Its ester functionality exhibits excellent bench stability and compatibility with standard coupling and reduction protocols. The ortho-ethoxy group provides directional control in electrophilic aromatic substitution and facilitates subsequent functionalization via directed ortho-metalation, offering predictable regioselectivity in complex molecule synthesis.

Synthesis

  • Route1
    • null|null
      64-67-5
    • Salicylic acid, ≥99%|CS-1268363
      69-72-7
    • ~80%
    • In-stock
      Ethyl 2-ethoxybenzoate|CS-0151456
      6290-24-0

    References

    • Kundu, Tapas Kumar; Balasubramanyam, Karanam; Swaminathan, Vankatesh Patent: US2006/167107 A1, 2006 ; Location in patent: Page/Page column 4 ; US 20060167107 A1
  • Route2
    • null|null
      60-29-7
    • null|null
      42926-52-3
    • ~70%
    • In-stock
      Ethyl 2-ethoxybenzoate|CS-0151456
      6290-24-0

    References

    • Yu, Yun-Feng; Gao, Jian-Rong; Jiang, Shao-Liang; Han, Liang; Jia, Jian-Hong; Li, Yu-Jin Asian Journal of Chemistry, 2012 , vol. 24, # 11 p. 5199 - 5201
  • Route3

    References

    • Journal of Chemical Research, , # 6 p. 307 - 309 Journal of Chemical Research, , # 7 p. 410 - 413

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   2.262
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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