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CS-W001157 4
Total: USD 88.00

1,6-Dibromo-n-hexane

  • CAS No. 629-03-8

  • Cat. No. CS-0015831
  • Purity≥98%
  • MDL No.MFCD00000272

*For research and further manufacturing use only, not for direct human use.

1,6-Dibromo-n-hexane|CS-0015831

Structure of 629-03-8

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General Information

  • CAS No. 629-03-8
  • Cat. No. CS-0015831
  • Purity ≥98%
  • MDL No. MFCD00000272
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂Br₂
  • Molecular Weight 243.97
  • Synonym(s) 1,6-Dibromohexane; Hexamethylene dibromide; NSC 7306
  • SMILES BrCCCCCCBr

Description

TCO-PEG8-TFP ester is a monodisperse crosslinker containing a TCO moiety and an PFP ester. The hydrophilic PEG8 arm increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label amine-containing antibodies, proteins and other macromolecules with TCO moiety. The PFP ester is amine-reactive, stable compound. PFP esters are less susceptible toward hydrolysis compared to NHS esters.

Application

1,6-Dibromo-n-hexane serves as a versatile dihalide building block for the synthesis of cyclic and linear polymers, including polyesters and polyamides. Its terminal bromine atoms enable efficient coupling reactions via SN2 mechanisms, facilitating chain extension under mild conditions. The compound exhibits good bench stability and ease of purification, making it well-suited for use in standard organic synthesis workflows requiring controlled molecular architecture.

Synthesis

  • Route1

    References

    • Chong, J. Michael; Heuft, Matthew A.; Rabbat, Phil Journal of Organic Chemistry, 2000 , vol. 65, # 18 p. 5837 - 5838
  • Route2
    • null|null
      1110667-69-0
    • ~4%
    • In-stock
      1,6-Dibromo-n-hexane|CS-0015831
      629-03-8
    • null|null
      57978-00-4

    References

    • Synthesis, , # 22 p. 3565 - 3568
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 58, p. 488 Archiv der Pharmazie (Weinheim, Germany), , p. 323 Zhurnal Obshchei Khimii, , vol. 5, p. 1508 Journal of the Chemical Society, , p. 46

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3082
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H317-H411
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.3366
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   5

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