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CS-W001157 4
Total: USD 88.00

Butane-1,4-diyl diacetate

  • CAS No. 628-67-1

  • Cat. No. CS-0128936
  • Purity≥98%
  • MDL No.MFCD00014984

*For research and further manufacturing use only, not for direct human use.

Butane-1,4-diyl diacetate|CS-0128936

Structure of 628-67-1

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General Information

  • CAS No. 628-67-1
  • Cat. No. CS-0128936
  • Purity ≥98%
  • MDL No. MFCD00014984
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄O₄
  • Molecular Weight 174.19
  • Synonym(s) Tetramethylene Diacetate
  • SMILES CC(OCCCCOC(C)=O)=O

Description

Butane-1,4-diyl diacetate is a bifunctional acetylating agent featuring two acetate ester groups at terminal positions of a butane backbone. This structure enables efficient, selective acetylation in synthetic transformations, particularly in polymer modification and small-molecule derivatization. The molecule exhibits favorable stability under standard conditions and facilitates clean reaction profiles with minimal side-product formation.

Application

Butane-1,4-diyl diacetate serves as a stable, bench-ready acetylating agent enabling efficient protection of primary alcohols in synthetic sequences. Its dual acetate functionality facilitates orthogonal derivatization in polyol systems, while the butanediyl linker provides structural flexibility for downstream transformations. The compound exhibits excellent functional group tolerance and simplifies purification due to low volatility and thermal stability, making it well-suited for scale-up in process chemistry and medicinal synthesis workflows.

Synthesis

  • Route1
    • null|null
      109-99-9
    • null|null
      108-24-7
    • ~10%
    • In-stock
      Butane-1,4-diyl diacetate|CS-0128936
      628-67-1

    References

    • Journal of Heterocyclic Chemistry, , vol. 37, # 5 p. 1351 - 1353
  • Route2
    • null|null
      110-63-4
    • null|null
      108-24-7
    • ~97%
    • In-stock
      Butane-1,4-diyl diacetate|CS-0128936
      628-67-1

    References

    • Journal of Chemical Research, , # 12 p. 802 - 805
  • Route3
    • 4-((Tetrahydro-2H-pyran-2-yl)oxy)butan-1-ol|CS-0168564
      51326-51-3
    • null|null
      108-24-7
    • ~97%
    • In-stock
      Butane-1,4-diyl diacetate|CS-0128936
      628-67-1

    References

    • Australian Journal of Chemistry, , vol. 60, # 1 p. 75 - 79

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   0.8928
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   5

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