Lot numbers can be found on the outside label of a product:
2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid
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CAS No. 62774-90-7
- Cat. No. CS-D0785
- Purity≥97%
- MDL No.MFCD02932724
*For research and further manufacturing use only, not for direct human use.
Structure of 62774-90-7
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General Information
- CAS No. 62774-90-7
- Cat. No. CS-D0785
- Purity ≥97%
- MDL No. MFCD02932724
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₅Cl₂NO₂
- Molecular Weight 206.03
- Synonym(s) 2,6-Dichloro-4-methylnicotinic acid; 2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid
- SMILES O=C(C1=C(C)C=C(Cl)N=C1Cl)O
Description
2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid features a sterically hindered pyridine core with electron-withdrawing chlorine substituents and a methyl group at the 4-position, enhancing its utility in synthesizing bioactive heterocycles. The carboxylic acid moiety enables direct coupling reactions under standard conditions. This compound serves as a key intermediate in medicinal chemistry applications requiring halogenated, electron-deficient pyridine scaffolds.
Application
2,6-Dichloro-4-methyl-3-pyridinecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyridine-based pharmaceutical intermediates. Its electron-deficient pyridine core facilitates nucleophilic substitution reactions, while the carboxylic acid and methyl groups provide orthogonal functionalization sites. The compound exhibits good bench stability and is compatible with standard coupling protocols, making it well-suited for modular scaffold construction in API development.
Synthesis
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Route1
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In-stock
38841-54-2 - ~98%
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In-stock
62774-90-7
References
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Wang, Yamin; Bullock, William H.; Chen, Libing Patent: US6677352 B1, 2004 ; Location in patent: Page/Page column 46 ;
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Route2
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In-stock
875-35-4 - ~98%
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In-stock
62774-90-7
References
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Wang, Yamin; Bullock, William H.; Chen, Libing Patent: US6677352 B1, 2004 ; Location in patent: Page/Page column 46 ;
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Route3
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In-stock
91591-70-7 - ~76%
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In-stock
62774-90-7
References
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Sarkar, Tarun K.; Ghosh, Sunil K.; Chow, Tahsin J. Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3111 - 3115
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 50.19
- LogP 2.39502
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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