Lot numbers can be found on the outside label of a product:
2,6-Dimethoxyisonicotinic acid
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CAS No. 6274-82-4
- Cat. No. CS-0150236
- Purity≥95%
- MDL No.MFCD18257556
*For research and further manufacturing use only, not for direct human use.
Structure of 6274-82-4
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General Information
- CAS No. 6274-82-4
- Cat. No. CS-0150236
- Purity ≥95%
- MDL No. MFCD18257556
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₉NO₄
- Molecular Weight None
- Synonym(s) 2,6 - diMethoxypyridine - 4 - carboxylic acid
- SMILES COC1=NC(=CC(=C1)C(=O)O)OC
Description
2,6-Dimethoxyisonicotinic acid features a para-substituted pyridine core with two methoxy groups at the 2- and 6-positions, enhancing solubility and modulating electronic properties. This bench-stable derivative serves as a key building block in medicinal chemistry, particularly for coupling reactions in drug discovery workflows.
Application
2,6-Dimethoxyisonicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds and bioactive molecules through established coupling reactions. Its ortho-dimethoxy substitution pattern enhances solubility and provides predictable reactivity in amide formation and Suzuki couplings, while maintaining bench stability and ease of purification.
Synthesis
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References
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Betschart, Claudia; Lerchner, Andreas; Machauer, Rainer; Rueger, Heinrich; Tintelnot-Blomley, Marina; Veenstra, Siem Jacob Patent: US2008/132477 A1, 2008 ; Location in patent: Page/Page column 25 ;
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Route2
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In-stock
42521-09-5 - ~%
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In-stock
6274-82-4
References
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McMillan et al. Journal of the American Pharmaceutical Association (1912-1977), 1953 , vol. 42, p. 457,463 Full Text Show Details Okajima; Seki Yakugaku Zasshi, 1953 , vol. 73, p. 845,846, 847 Chem.Abstr., 1954 , p. 10021
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Route3
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In-stock
5398-44-7 - ~%
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In-stock
6274-82-4
References
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McMillan et al. Journal of the American Pharmaceutical Association (1912-1977), 1953 , vol. 42, p. 457,463 Full Text Show Details Okajima; Seki Yakugaku Zasshi, 1953 , vol. 73, p. 845,846, 847 Chem.Abstr., 1954 , p. 10021
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Safety Information
Download SDS|
GHS Pictogram :
N/A
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GHS No : N/A
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Signal Word : N/A
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : N/A
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Precautionary Statements : N/A
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Quality Control
Computational Chemistry Data
- TPSA 68.65
- LogP 0.797
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 3
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Key Words
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