Lot numbers can be found on the outside label of a product:
4-Amino-N-methylbenzamide
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CAS No. 6274-22-2
- Cat. No. CS-W018773
- Purity≥98%
- MDL No.MFCD00665792
*For research and further manufacturing use only, not for direct human use.
Structure of 6274-22-2
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General Information
- CAS No. 6274-22-2
- Cat. No. CS-W018773
- Purity ≥98%
- MDL No. MFCD00665792
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₁₀N₂O
- Molecular Weight 150.18
- Synonym(s) Benzamide, 4-amino-N-methyl- (9CI); 4-Amino-N-methylbenzamide
- SMILES CNC(=O)C1=CC=C(N)C=C1
Description
4-Amino-N-methylbenzamide features a para-amino group and a methylated amide, delivering enhanced solubility and metabolic stability. This combination enables efficient incorporation into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.
Application
4-Amino-N-methylbenzamide serves as a versatile building block in medicinal chemistry, enabling direct incorporation of an electron-rich aniline moiety with enhanced metabolic stability via N-methylation. Its dual functionality—amine and amide—facilitates diverse coupling reactions and downstream derivatization, while the methylated amide enhances solubility and reduces hydrogen-bonding capacity. The compound exhibits excellent bench stability and is readily purified by crystallization or chromatography, making it ideal for use in API intermediate synthesis and combinatorial library construction.
Synthesis
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Route1
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In-stock
2585-23-1 - ~85%
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In-stock
6274-22-2
References
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US2009/239848 A1, ; Page/Page column 24 ; US 20090239848 A1
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Route2
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1719-57-9 -
In-stock
2835-68-9 - ~82%
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In-stock
6274-22-2
References
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Tetrahedron Letters, , vol. 41, # 25 p. 4933 - 4936
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Route3
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122-04-3
- ~%
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In-stock
6274-22-2
References
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Journal of Medicinal Chemistry, , vol. 27, # 6 p. 779 - 782
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Quality Control
Computational Chemistry Data
- TPSA 55.12
- LogP 0.6284
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
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