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(R)-1-Methoxypropan-2-amine hydrochloride

  • CAS No. 626220-76-6

  • Cat. No. CS-W019198
  • Molecule weight125.60
  • Purity≥97%
  • MDL No.MFCD12405301

*For research and further manufacturing use only, not for direct human use.

(R)-1-Methoxypropan-2-amine hydrochloride|CS-W019198

Structure of 626220-76-6

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General Information

  • CAS No. 626220-76-6
  • Cat. No. CS-W019198
  • Purity ≥97%
  • MDL No. MFCD12405301
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₂ClNO
  • Molecular Weight 125.60
  • Synonym(s) (R)-1-Methoxypropan-2-amine, HCl
  • SMILES C[C@@H](N)COC.[H]Cl

Description

(R)-1-Methoxypropan-2-amine hydrochloride is a chiral amine derivative featuring a methoxy-substituted carbon adjacent to a primary amine. This bench-stable, moisture-tolerant compound serves as a key building block in asymmetric synthesis, enabling stereoselective coupling reactions. Its hydrochloride salt enhances solubility and handling in aqueous or protic media, streamlining integration into peptide and small-molecule drug discovery workflows.

Application

(R)-1-Methoxypropan-2-amine hydrochloride serves as a chiral building block for medicinal chemistry and asymmetric synthesis, offering a stable, bench-ready amine with high functional group tolerance. Its pendant methoxy group enhances solubility and modulates reactivity, enabling efficient incorporation into diverse scaffolds via amidation, alkylation, or coupling reactions. The hydrochloride salt ensures excellent crystallinity and ease of handling, facilitating purification and scalability in API development workflows.

Synthesis

  • Route1
    • null|null
      955399-15-2
    • ~98%
    • In-stock
      (R)-1-Methoxypropan-2-amine hydrochloride|CS-W019198
      626220-76-6

    References

    • Roche Palo Alto LLC Patent: US2009/163502 A1, 2009 ; Location in patent: Page/Page column 40 ;
  • Route2
    • null|null
      1381925-39-8
    • ~99%
    • In-stock
      (R)-1-Methoxypropan-2-amine hydrochloride|CS-W019198
      626220-76-6

    References

    • Harris, III, Ralph New; Repke, David Bruce; Walker, Keith A.M. Patent: US2012/157494 A1, 2012 ; Location in patent: Page/Page column 27-28 ; US 20120157494 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   0.4018
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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