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CS-W001157 4
Total: USD 88.00

Di-m-tolylamine

  • CAS No. 626-13-1

  • Cat. No. CS-W010562
  • Molecule weight197.28
  • Purity≥97%
  • MDL No.MFCD00059315

*For research and further manufacturing use only, not for direct human use.

Di-m-tolylamine|CS-W010562

Structure of 626-13-1

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General Information

  • CAS No. 626-13-1
  • Cat. No. CS-W010562
  • Purity ≥97%
  • MDL No. MFCD00059315
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₅N
  • Molecular Weight 197.28
  • Synonym(s) 3,3'-Dimethyldiphenylamine
  • SMILES CC1=CC(NC2=CC=CC(C)=C2)=CC=C1

Description

Di-m-tolylamine features a symmetric bis(ortho-tolyl) structure that imparts enhanced steric protection and electronic stabilization. This bench-stable compound serves as a robust scaffold in cross-coupling reactions and transition-metal catalysis, where its electron-rich aryl groups facilitate oxidative addition and ligand exchange.

Application

Di-m-tolylamine serves as a stable, bench-ready aryl amine scaffold for constructing biaryl systems and heterocyclic frameworks. Its ortho-methyl substituents enhance steric shielding and oxidative stability, enabling reliable coupling reactions with palladium catalysts. The molecule functions effectively in Suzuki-Miyaura, Buchwald-Hartwig, and nitration protocols, offering predictable regiochemistry and straightforward purification via crystallization or column chromatography.

Synthesis

  • Route1

    References

    • Zhou, Changfeng; Yang, Dongpeng; Jia, Xiaofei; Zhang, Lixue; Cheng, Jiang Synlett, 2009 , # 19 p. 3198 - 3200
  • Route2
    • null|null
      1422-76-0
    • ~8%
    • In-stock
      3,3'-Dimethyl-1,1'-biphenyl|CS-0153225
      612-75-9
    • In-stock
      Di-m-tolylamine|CS-W010562
      626-13-1
    • null|null
      588-04-5

    References

    • Electrochemistry Communications, , vol. 12, # 7 p. 973 - 976
  • Route3

    References

    • Tlili, Anis; Monnier, Florian; Taillefer, Marc Chemical Communications, 2012 , vol. 48, # 51 p. 6408 - 6410

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   4.04704
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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