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Chloromethyl acetate

  • CAS No. 625-56-9

  • Cat. No. CS-0139458
  • Molecule weight108.52
  • Purity≥95%
  • MDL No.MFCD00623643

*For research and further manufacturing use only, not for direct human use.

Chloromethyl acetate|CS-0139458

Structure of 625-56-9

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General Information

  • CAS No. 625-56-9
  • Cat. No. CS-0139458
  • Purity ≥95%
  • MDL No. MFCD00623643
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₅ClO₂
  • Molecular Weight 108.52
  • Synonym(s) Methanol, chloro-, acetate
  • SMILES CC(OCCl)=O

Description

Chloromethyl acetate is a reactive acylating agent featuring a chloromethyl group attached to an ester moiety. This compound facilitates efficient alkylation under mild conditions, enabling direct functionalization of nucleophiles without requiring strong bases. The molecule exhibits high reactivity toward amines and thiols, delivering stable ether and thioether products. Its moderate stability under standard handling allows for controlled reaction kinetics in synthetic workflows.

Application

Chloromethyl acetate serves as a versatile acetylating and chloromethylating agent, enabling efficient introduction of both acetyl and chloromethyl groups in sequential or one-pot transformations. Its bench-stable liquid form facilitates handling, while broad functional group tolerance supports use in complex molecule synthesis. Functions effectively in nucleophilic substitution reactions, particularly for preparing acetate-protected intermediates or generating reactive alkylating species under mild conditions.

Synthesis

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      75-36-5
    • ~83%
    • In-stock
      Chloromethyl acetate|CS-0139458
      625-56-9

    References

    • Mustafaev; Kulieva; Kulibekova; Kakhramanova; Safarova; Novotorzhina Russian Journal of Organic Chemistry, 2013 , vol. 49, # 2 p. 198 - 203 Zh. Org. Khim., 2013 , vol. 49, # 2 p. 210 - 214,5
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      79-20-9
    • ~%
    • In-stock
      Chloromethyl acetate|CS-0139458
      625-56-9

    References

    • Chemische Berichte, , vol. 6, p. 741 Chem. Zentralbl., , vol. 71, # I p. 594 Chem. Zentralbl., , vol. 71, # I p. 594 US2302228 , ; Bulletin des Societes Chimiques Belges, , vol. 58, p. 315
  • Route3
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      50-00-0
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      75-36-5
    • ~87%
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      542-88-1
    • In-stock
      Chloromethyl acetate|CS-0139458
      625-56-9

    References

    • Tendler, Saul J. B.; Threadgill, Michael D.; Tisdale, Michael J. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2617 - 2624

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅱ
Hazard Statements : H225-H314-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P261-P264-P271-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   0.7458
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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