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CS-W001157 4
Total: USD 88.00

Chloromethyl acetate

  • CAS No. 625-56-9

  • Cat. No. CS-0139458
  • Purity≥95%
  • MDL No.MFCD00623643
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Chloromethyl acetate|CS-0139458

Structure of 625-56-9

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Description

Chloromethyl acetate is a reactive acylating agent featuring a chloromethyl group attached to an ester moiety. This compound facilitates efficient alkylation under mild conditions, enabling direct functionalization of nucleophiles without requiring strong bases. The molecule exhibits high reactivity toward amines and thiols, delivering stable ether and thioether products. Its moderate stability under standard handling allows for controlled reaction kinetics in synthetic workflows.

Application

Chloromethyl acetate serves as a versatile acetylating and chloromethylating agent, enabling efficient introduction of both acetyl and chloromethyl groups in sequential or one-pot transformations. Its bench-stable liquid form facilitates handling, while broad functional group tolerance supports use in complex molecule synthesis. Functions effectively in nucleophilic substitution reactions, particularly for preparing acetate-protected intermediates or generating reactive alkylating species under mild conditions.

General Information

  • CAS No. 625-56-9
  • Cat. No. CS-0139458
  • Purity ≥95%
  • MDL No. MFCD00623643
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₅ClO₂
  • Molecular Weight 108.52
  • Synonym(s) Methanol, chloro-, acetate
  • SMILES CC(OCCl)=O

Computational Chemistry Data

  • TPSA   26.3
  • LogP   0.7458
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group :
Hazard Statements : H225-H314-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P261-P264-P271-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

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