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CS-W001157 4
Total: USD 88.00

2-(4-Fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 624741-83-9

  • Cat. No. CS-0173920
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(4-Fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0173920

Structure of 624741-83-9

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General Information

  • CAS No. 624741-83-9
  • Cat. No. CS-0173920
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈BFO₃
  • Molecular Weight 252.09
  • Synonym(s) 4-Fluoro-2-methoxyphenylboronic acid pinacol ester
  • SMILES CC1(C(C)(OB(O1)C2=C(OC)C=C(F)C=C2)C)C

Description

This boronate ester features a 4-fluoro-2-methoxyphenyl group coupled to a stable tetramethyl-1,3,2-dioxaborolane scaffold. The electron-deficient aryl moiety enables efficient Suzuki-Miyaura coupling, while the sterically hindered dioxaborolane enhances shelf life and moisture tolerance under standard conditions.

Application

2-(4-Fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. Its ortho-methoxy and para-fluoro substituents provide directed functionalization potential and enhanced reactivity in palladium-catalyzed transformations. The tetramethyl-substituted dioxaborolane core ensures excellent air stability, ease of handling, and compatibility with diverse reaction conditions, enabling efficient construction of complex aryl scaffolds in medicinal chemistry and materials synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   2.1335
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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