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CS-W001157 4
Total: USD 88.00

2-Iodoacetonitrile

  • CAS No. 624-75-9

  • Cat. No. CS-W016050
  • Purity≥96%
  • MDL No.MFCD00001886

*For research and further manufacturing use only, not for direct human use.

2-Iodoacetonitrile|CS-W016050

Structure of 624-75-9

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General Information

  • CAS No. 624-75-9
  • Cat. No. CS-W016050
  • Purity ≥96%
  • MDL No. MFCD00001886
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₂IN
  • Molecular Weight 166.95
  • Synonym(s) Iodoacetonitrile
  • SMILES N#CCI

Description

2-Iodoacetonitrile is a reactive electrophilic reagent featuring a nitrile group flanked by an iodine-substituted methylene moiety. This configuration enables efficient alkylation of nucleophiles, particularly thiols and amines, under mild conditions. The compound exhibits high stability in storage and compatibility with diverse reaction media, facilitating its use in bioconjugation and synthetic methodology development.

Synthesis

  • Route1
    • null|null
      590-17-0
    • ~97%
    • In-stock
      2-Iodoacetonitrile|CS-W016050
      624-75-9

    References

    • SCHOOL OF PHARMACY, UNIVERSITY OF LONDON Patent: WO2005/61453 A1, 2005 ; Location in patent: Page/Page column 15 ;
  • Route2
    • null|null
      107-14-2
    • ~%
    • In-stock
      2-Iodoacetonitrile|CS-W016050
      624-75-9

    References

    • Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 6 p. 981 - 984
  • Route3
    • null|null
      16728-83-9
    • null|null
      74-88-4
    • ~%
    • In-stock
      2-Iodoacetonitrile|CS-W016050
      624-75-9
    • Trimethylphenylammonium iodide|CS-W010139
      98-04-4

    References

    • Chemische Berichte, , vol. 41, p. 2117 Chemische Berichte, , vol. 42, p. 2056

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2922
Class : 8 (6.1)
Packing Group : Ⅱ
Hazard Statements : H227-H301-H314
Precautionary Statements : P210-P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.79
  • LogP   0.94498
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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