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Structure of 623918-49-0
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Ethyl 5-iodo-1H-indole-2-carboxylate features a sterically accessible indole core functionalized at the 5-position with a reactive iodine atom. This electrophilic handle enables efficient cross-coupling reactions in late-stage diversification of heterocyclic scaffolds. The ester group provides solubility and stability under standard conditions, facilitating integration into synthetic sequences for medicinal chemistry and materials science applications.
Ethyl 5-iodo-1H-indole-2-carboxylate serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation at the 5-position of the indole scaffold. The iodide group exhibits high reactivity in standard Suzuki, Stille, and Negishi couplings, while the ester functionality provides compatibility with subsequent transformations such as hydrolysis or reduction. Its bench stability and straightforward purification make it well-suited for iterative synthesis of functionalized indole derivatives used in medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H317
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Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: