(S)-(4,4-Difluoropyrrolidin-2-yl)methanol hydrochloride

Name: (S)-(4,4-Difluoropyrrolidin-2-yl)methanol hydrochloride
Brand: ChemScene
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CAS No. 623583-10-8
Cat. No. CS-0038151
Purity≥97%
MDL No.MFCD22570251

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(S)-(4,4-Difluoropyrrolidin-2-yl)methanol hydrochloride|CS-0038151

Structure of 623583-10-8

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Description

(S)-(4,4-Difluoropyrrolidin-2-yl)methanol hydrochloride features a stereodefined pyrrolidine core with dual fluorine atoms at the 4-position, conferring enhanced metabolic stability and modulated lipophilicity. This bench-stable derivative integrates readily into medicinal chemistry campaigns requiring constrained, electron-deficient heterocycles with improved solubility profiles for target engagement in CNS-directed drug discovery.

Application

(S)-(4,4-Difluoropyrrolidin-2-yl)methanol hydrochloride serves as a conformationally constrained building block for medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its bench-stable hydrochloride salt facilitates handling and purification, while the difluoropyrrolidine core provides enhanced metabolic stability and favorable physicochemical properties. Functions effectively in amide coupling and nucleophilic substitution reactions, supporting the synthesis of bioactive molecules with improved membrane permeability.

General Information

CAS No. 623583-10-8
Cat. No. CS-0038151
Purity ≥97%
MDL No. MFCD22570251
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₀ClF₂NO
Molecular Weight 173.59
Synonym(s) [(2S)-4,4-difluoropyrrolidin-2-yl]methanol hydrochloride
SMILES OC[C@@H]1CC(F)(F)CN1.Cl

Computational Chemistry Data

TPSA 32.26
LogP 0.3977
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(S)-(4,4-Difluoropyrrolidin-2-yl)methanol hydrochloride

CAS No. 623583-10-8

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