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CS-W001157 4
Total: USD 88.00

N-(3-Bromophenyl)acetamide

  • CAS No. 621-38-5

  • Cat. No. CS-0089812
  • Purity≥98%
  • MDL No.MFCD00461391

*For research and further manufacturing use only, not for direct human use.

N-(3-Bromophenyl)acetamide|CS-0089812

Structure of 621-38-5

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General Information

  • CAS No. 621-38-5
  • Cat. No. CS-0089812
  • Purity ≥98%
  • MDL No. MFCD00461391
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrNO
  • Molecular Weight 214.06
  • Synonym(s) n-(3-bromophenyl)-acetamid
  • SMILES CC(NC1=CC=CC(Br)=C1)=O

Description

N-(3-Bromophenyl)acetamide is a bench-stable aryl amide featuring a brominated aromatic ring and a reactive acetamide group. This compound serves as a key intermediate in medicinal chemistry, enabling direct coupling reactions and facilitating the construction of complex heterocycles under standard conditions.

Application

N-(3-Bromophenyl)acetamide serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable aryl bromide functionality. The acetamide group provides enhanced solubility and facilitates purification, while the ortho-substituted aromatic system offers predictable reactivity in Suzuki-Miyaura and Buchwald-Hartwig transformations. This compound functions reliably in multi-step syntheses of bioactive heterocycles and pharmaceutical intermediates.

Synthesis

  • Route1
    • null|null
      108-24-7
    • null|null
      591-19-5
    • ~99%
    • In-stock
      N-(3-Bromophenyl)acetamide|CS-0089812
      621-38-5

    References

    • WO2006/18326 A1, ; Page/Page column 54 ; WO 2006/018326 A1
  • Route2
    • null|null
      75-36-5
    • null|null
      591-19-5
    • ~99%
    • In-stock
      N-(3-Bromophenyl)acetamide|CS-0089812
      621-38-5

    References

    • WO2011/130628 A1, ; Page/Page column 168-169 ; WO 2011/130628 A1
  • Route3
    • 2-Amino-4-fluorobenzoic acid Afatinib Impurity|CS-0167288
      446-32-2
    • ~76%
    • In-stock
      N-(3-Bromophenyl)acetamide|CS-0089812
      621-38-5

    References

    • US6777428 B1, ; Page column 25 ; US 6777428 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   2.4075
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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