2,6-Dichloronicotinamide

Name: 2,6-Dichloronicotinamide
Brand: ChemScene
Availability: InStock
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CAS No. 62068-78-4
Cat. No. CS-W013221
Purity≥98%
MDL No.MFCD03230010

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 62068-78-4
Cat. No. CS-W013221
Purity ≥98%
MDL No. MFCD03230010
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄Cl₂N₂O
Molecular Weight 191.01
Synonym(s) 2,6-Dichloropyridine-3-carboxamide
SMILES NC(C1=CC=C(N=C1Cl)Cl)=O

Description

2,6-Dichloronicotinamide features a rigid pyridine core with electron-withdrawing chlorine substituents at the 2 and 6 positions, enhancing its stability and reactivity in synthetic transformations. This derivative serves as a key scaffold in medicinal chemistry for targeting kinase pathways and other biological systems requiring precise electronic tuning.

Application

2,6-Dichloronicotinamide serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through direct coupling and cyclization reactions. Its ortho-chlorine substituents facilitate palladium-catalyzed cross-couplings and nucleophilic aromatic substitution, while the amide functionality offers synthetic handle for derivatization. Bench-stable and readily purified, it functions effectively in API development workflows requiring functional group tolerance and predictable reactivity.

Synthesis

Route1
- 58584-83-1
- ~55%
- In-stock
  
  62068-78-4
References
- Bach, Peter; Marczynke, Michaela; Giordanetto, Fabrizio European Journal of Organic Chemistry, 2012 , # 35 p. 6940 - 6952

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P302+P352

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Computational Chemistry Data

TPSA 55.98
LogP 1.4873
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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2,6-Dichloronicotinamide

CAS No. 62068-78-4

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