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CS-W001157 4
Total: USD 88.00

Ethyl 2-amino-5-bromothiazole-4-carboxylate

  • CAS No. 61830-21-5

  • Cat. No. CS-0019254
  • Purity≥97%
  • MDL No.MFCD06669909

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-amino-5-bromothiazole-4-carboxylate|CS-0019254

Structure of 61830-21-5

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General Information

  • CAS No. 61830-21-5
  • Cat. No. CS-0019254
  • Purity ≥97%
  • MDL No. MFCD06669909
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BrN₂O₂S
  • Molecular Weight 251.10
  • Synonym(s) Ethyl 2-Amino-5-bromothiazole-4-carboxylicacid
  • SMILES O=C(C1=C(Br)SC(N)=N1)OCC

Description

Ethyl 2-amino-5-bromothiazole-4-carboxylate features a brominated thiazole core with complementary amino and ester functionalities, enabling direct incorporation into heterocyclic scaffolds. This bench-stable reagent facilitates efficient access to medicinally relevant thiazole derivatives through coupling and cyclization processes under standard conditions.

Application

Ethyl 2-amino-5-bromothiazole-4-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to thiazole-based scaffolds prevalent in medicinal chemistry. The amino and bromo groups offer orthogonal handles for palladium-catalyzed cross-coupling and electrophilic substitution, while the ester functionality supports further derivatization. Its bench-stable nature and compatibility with standard reaction conditions facilitate reliable incorporation into complex molecular architectures.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 20, p. 572 - 576
  • Route2
    • In-stock
      Ethyl 2-aminothiazole-4-carboxylate|CS-W009022
      5398-36-7
    • null|null
      70-23-5
    • ~%
    • In-stock
      Ethyl 2-amino-5-bromothiazole-4-carboxylate|CS-0019254
      61830-21-5

    References

    • US5705516 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   1.6645
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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