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CS-W001157 4
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2-Amino-3-chlorobenzenemethanol

  • CAS No. 61487-25-0

  • Cat. No. CS-0019252
  • Purity≥98%
  • MDL No.MFCD13193432

*For research and further manufacturing use only, not for direct human use.

2-Amino-3-chlorobenzenemethanol|CS-0019252

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General Information

  • CAS No. 61487-25-0
  • Cat. No. CS-0019252
  • Purity ≥98%
  • MDL No. MFCD13193432
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClNO
  • Molecular Weight 157.60
  • Synonym(s) 2-Amino-3-chlorobenzyl alcohol; (2-Amino-3-chlorophenyl)methanol
  • SMILES OCC1=CC=CC(Cl)=C1N

Description

2-Amino-3-chlorobenzenemethanol features a strategically positioned amino group flanked by a chloro substituent and a hydroxymethyl moiety, enabling direct integration into bioactive molecule scaffolds. This bench-stable derivative supports efficient derivatization in medicinal chemistry workflows.

Application

2-Amino-3-chlorobenzenemethanol serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted benzimidazoles and other heterocyclic scaffolds. Its ortho-halogenated aryl core facilitates palladium-catalyzed coupling reactions, while the amino and hydroxymethyl groups offer orthogonal functionalization potential. The compound exhibits good bench stability and is readily purified by recrystallization or column chromatography, supporting its use in multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • Bristol-Myers Squibb Company Patent: US2007/259850 A1, 2007 ; Location in patent: Page/Page column 99 ; US 20070259850 A1
  • Route2

    References

    • Bristol-Myers Squibb Company Patent: US2007/219370 A1, 2007 ; Location in patent: Page/Page column 24; 25 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.4145
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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