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CS-W001157 4
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2-Methylquinolin-3-ol

  • CAS No. 613-19-4

  • Cat. No. CS-0236805
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Methylquinolin-3-ol|CS-0236805

Structure of 613-19-4

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General Information

  • CAS No. 613-19-4
  • Cat. No. CS-0236805
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO
  • Molecular Weight 159.18
  • Synonym(s) 3-Hydroxyquinaldine
  • SMILES CC1=NC2=C(C=CC=C2)C=C1O

Description

2-Methylquinolin-3-ol features a fused quinoline core with a methyl group at the 2-position and a phenolic hydroxyl at the 3-position, delivering enhanced solubility and stability compared to unsubstituted analogs. This scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitors and fluorescent probes, where its electron-rich aromatic system supports π-stacking interactions. The compound exhibits bench-stable handling under standard conditions and serves as a direct precursor for diverse heterocyclic transformations.

Application

2-Methylquinolin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to quinoline-based scaffolds through standard functional group transformations. Its phenolic hydroxyl and methyl-substituted quinoline core offer enhanced stability and compatibility with common coupling reactions, facilitating downstream derivatization for drug discovery applications.

Synthesis

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    • In-stock
      2-Methylquinolin-3-ol|CS-0236805
      613-19-4

    References

    • Cross; Henze Journal of the American Chemical Society, 1939 , vol. 61, p. 2730,2732
  • Route2
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      811432-11-8
    • ~%
    • In-stock
      2-Methylquinolin-3-ol|CS-0236805
      613-19-4

    References

    • Cross; Henze Journal of the American Chemical Society, 1939 , vol. 61, p. 2730,2732
  • Route3

    References

    • Cross; Henze Journal of the American Chemical Society, 1939 , vol. 61, p. 2730,2732

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.24882
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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