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CS-W001157 4
Total: USD 88.00

4-Bromo-2-methyl-1H-indole

  • CAS No. 6127-18-0

  • Cat. No. CS-W005700
  • Purity≥95%
  • MDL No.MFCD18380829

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-methyl-1H-indole|CS-W005700

Structure of 6127-18-0

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General Information

  • CAS No. 6127-18-0
  • Cat. No. CS-W005700
  • Purity ≥95%
  • MDL No. MFCD18380829
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈BrN
  • Molecular Weight 210.07
  • Synonym(s) TOSLAB 23085
  • SMILES CC(N1)=CC2=C1C=CC=C2Br

Description

4-Bromo-2-methyl-1H-indole is a brominated indole derivative featuring a methyl group at the 2-position and a bromine atom at the 4-position, offering enhanced electron density and reactivity. This bench-stable compound serves as a key building block in medicinal chemistry, enabling efficient access to functionalized heterocycles through cross-coupling and electrophilic substitution reactions.

Application

4-Bromo-2-methyl-1H-indole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for C–C bond formation. Its bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the methyl group enhances solubility and modulates electronic properties. The indole core offers robust stability under standard reaction conditions, facilitating efficient synthesis of complex heterocyclic scaffolds and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   3.23882
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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