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CS-W001157 4
Total: USD 88.00

6-Chloroquinoline

  • CAS No. 612-57-7

  • Cat. No. CS-W007925
  • Purity≥98%
  • MDL No.MFCD00024024

*For research and further manufacturing use only, not for direct human use.

6-Chloroquinoline|CS-W007925

Structure of 612-57-7

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General Information

  • CAS No. 612-57-7
  • Cat. No. CS-W007925
  • Purity ≥98%
  • MDL No. MFCD00024024
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆ClN
  • Molecular Weight 163.60
  • Synonym(s) 6-chloro-quinolin; 6-Chloroquinoline
  • SMILES C1=C(C=C2C(=C1)N=CC=C2)Cl

Description

6-Chloroquinoline is a heterocyclic compound featuring a chlorine atom at the 6-position of the quinoline core. This electron-deficient scaffold serves as a key building block in medicinal chemistry, enabling direct functionalization in cross-coupling reactions. The chloro group enhances reactivity for nucleophilic substitution and facilitates incorporation into bioactive molecules, particularly in kinase inhibitors and fluorescent probes.

Synthesis

  • Route1
    • 4-Chloro-N-(prop-2-yn-1-yl)aniline|CS-0094915
      22774-67-0
    • ~65%
    • In-stock
      6-Chloroquinoline|CS-W007925
      612-57-7
    • null|null
      13519-80-7

    References

    • Tetrahedron, , vol. 69, # 23 p. 4612 - 4616
  • Route2
    • In-stock
      3,3',3''-Nitrilotris(propan-1-ol)|CS-0590861
      14002-34-7
    • null|null
      100-00-5
    • ~86%
    • In-stock
      6-Chloroquinoline|CS-W007925
      612-57-7

    References

    • Cho, Chan Sik; Lee, Na Young; Choi, Heung-Jin; Kim, Tae-Jeong; Shim, Sang Chul Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 5 p. 929 - 932
  • Route3
    • Quinolin-6-yl trifluoromethanesulfonate|CS-W016719
      173089-80-0
    • ~77%
    • In-stock
      6-Chloroquinoline|CS-W007925
      612-57-7

    References

    • Pan, Jun; Wang, Xinyan; Zhang, Yong; Buchwald, Stephen L. Organic Letters, 2011 , vol. 13, # 18 p. 4974 - 4976

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.8882
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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