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4-hydroxy-N-methylpicolinamide Regorafenib Impurity

  • CAS No. 611226-36-9

  • Cat. No. CS-0163817
  • Purity≥97%
  • MDL No.MFCD16998396

*For research and further manufacturing use only, not for direct human use.

4-hydroxy-N-methylpicolinamide  Regorafenib Impurity|CS-0163817

Structure of 611226-36-9

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General Information

  • CAS No. 611226-36-9
  • Cat. No. CS-0163817
  • Purity ≥97%
  • MDL No. MFCD16998396
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O₂
  • Molecular Weight None
  • Synonym(s) 2-Pyridinecarboxamide, 4-hydroxy-N-methyl- (9CI)
  • SMILES O=C(NC)C1=NC=CC(O)=C1

Synthesis

  • Route1
    • 4-Chloro-N-methyl-2-pyridinecarboxamide Sorafenib Impurity|CS-0181543
      220000-87-3
    • ~%
    • 4-hydroxy-N-methylpicolinamide  Regorafenib Impurity|CS-0163817
      611226-36-9

    References

    • Ramurthy, Savithri; Subramanian, Sharadha; Aikawa, Mina; Amiri, Payman; Costales, Abran; Dove, Jeff; Fong, Susan; Jansen, Johanna M.; Levine, Barry; Ma, Sylvia; McBride, Christopher M.; Michaelian, Jonah; Pick, Teresa; Poon, Daniel J.; Girish, Sandhya; Shafer, Cynthia M.; Stuart, Darrin; Sung, Leonard; Renhowe, Paul A. Journal of Medicinal Chemistry, 2008 , vol. 51, # 22 p. 7049 - 7052

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   62.22
  • LogP   0.1468
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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