Lot numbers can be found on the outside label of a product:
4-Chloroquinoline
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CAS No. 611-35-8
- Cat. No. CS-W007603
- Purity≥98%
- MDL No.MFCD00006773
*For research and further manufacturing use only, not for direct human use.
Structure of 611-35-8
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General Information
- CAS No. 611-35-8
- Cat. No. CS-W007603
- Purity ≥98%
- MDL No. MFCD00006773
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₆ClN
- Molecular Weight 163.60
- Synonym(s) None
- SMILES C1=CC=CC2=C(C=CN=C12)Cl
Description
4-Chloroquinoline is a heterocyclic compound featuring a chlorine atom at the 4-position of the quinoline core. This electron-deficient scaffold serves as a key building block in medicinal chemistry, enabling efficient coupling reactions and facilitating the development of bioactive molecules with enhanced metabolic stability and target affinity.
Application
4-Chloroquinoline serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling direct functionalization at the C4 position via palladium-catalyzed cross-coupling reactions. Its stability under standard reaction conditions and compatibility with diverse functional groups make it a practical scaffold for constructing quinoline-based pharmaceuticals and ligands.
Synthesis
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Route1
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In-stock
611-36-9 - ~92%
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In-stock
611-35-8
References
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RUTGERS, THE STATE UNIVERSITY; LAVOIE, Edmond, J.; RUCHELMAN, Alexander, L.; LIU, Leroy, F. Patent: WO2004/14906 A2, 2004 ; Location in patent: Page 35 ;
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Route2
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4637-59-6 - ~89%
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In-stock
611-35-8
References
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Malinowski, Marek; Kaczmarek, Lukasz Synthesis, 1987 , # 11 p. 1013 - 1015
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Route3
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In-stock
529-37-3 - ~90%
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In-stock
611-35-8
References
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Ruchelman, Alexander L.; Kerrigan, John E.; Li, Tsai-Kun; Zhou, Nai; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 13 p. 3731 - 3742
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 2.8882
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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