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CS-W001157 4
Total: USD 88.00

2-Hydroxybenzonitrile

  • CAS No. 611-20-1

  • Cat. No. CS-W013585
  • Purity≥98%
  • MDL No.MFCD00002145

*For research and further manufacturing use only, not for direct human use.

2-Hydroxybenzonitrile|CS-W013585

Structure of 611-20-1

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General Information

  • CAS No. 611-20-1
  • Cat. No. CS-W013585
  • Purity ≥98%
  • MDL No. MFCD00002145
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅NO
  • Molecular Weight 119.12
  • Synonym(s) None
  • SMILES C1=CC=CC(=C1C#N)O

Description

2-Hydroxybenzonitrile may be used in the preparation of:methyl-(2-cyanophenoxy)acetate3-amino-N-phenylbenzofuran-2-carboxamide2-(2-oxo-2-phenylethoxy)benzonitrile3-amino-2-cyanobenzo[b]furaneIt may also be used as a directing group for meta-selective C-H bond alkenylation.

Application

2-Hydroxybenzonitrile serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted salicylonitriles and heterocyclic scaffolds. Its ortho-hydroxynitrile motif offers enhanced reactivity in cyclization reactions and facilitates downstream functionalization via nitrile hydrolysis or nucleophilic addition. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      90-02-8
    • ~93%
    • In-stock
      2-Hydroxybenzonitrile|CS-W013585
      611-20-1

    References

    • Ghosh, Pranab; Subba, Raju Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4885 - 4887
  • Route2
    • null|null
      2042-37-7
    • ~81%
    • In-stock
      2-Hydroxybenzonitrile|CS-W013585
      611-20-1

    References

    • Gallon, Benjamin J.; Kojima, Robert W.; Kaner, Richard B.; Diaconescu, Paula L. Angewandte Chemie - International Edition, 2007 , vol. 46, # 38 p. 7251 - 7254
  • Route3
    • (E)-2-Hydroxybenzaldehyde oxime|CS-0309097
      21013-96-7
    • ~99%
    • In-stock
      2-Hydroxybenzonitrile|CS-W013585
      611-20-1

    References

    • De Luca, Lidia; Giacomelli, Giampaolo; Porcheddu, Andrea Journal of Organic Chemistry, 2002 , vol. 67, # 17 p. 6272 - 6274

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H317-H318
Precautionary Statements : P261-P261-P264-P280-P280-P302+P352-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   44.02
  • LogP   1.26388
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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