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CS-W001157 4
Total: USD 88.00

4-Amino-2-fluorobenzamide

  • CAS No. 609783-45-1

  • Cat. No. CS-0038662
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Amino-2-fluorobenzamide|CS-0038662

Structure of 609783-45-1

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General Information

  • CAS No. 609783-45-1
  • Cat. No. CS-0038662
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FN₂O
  • Molecular Weight 154.14
  • Synonym(s) Enzalutamide Impurity 23
  • SMILES C1=CC(=C(C=C1N)F)C(=O)N

Description

4-Amino-2-fluorobenzamide is a fluorinated aromatic amide featuring a para-amino group and ortho-fluorine substitution, enabling enhanced electronic modulation in synthetic intermediates. This bench-stable compound integrates readily into pharmaceutical scaffolds, offering improved solubility and metabolic stability in bioactive molecule design.

Application

4-Amino-2-fluorobenzamide serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds and bioactive compounds. Its ortho-fluoro and amino groups facilitate directed metalation and selective functionalization, while the amide functionality provides stability and solubility advantages. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • 2-Fluoro-4-nitrobenzamide|CS-0205811
      350-32-3
    • ~71%
    • In-stock
      4-Amino-2-fluorobenzamide|CS-0038662
      609783-45-1

    References

    • Sumitomo Pharmaceuticals Company, Limited Patent: EP1500643 A1, 2005 ; Location in patent: Page 38 ; EP 1500643 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   69.11
  • LogP   0.5068
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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