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CS-W001157 4
Total: USD 88.00

4-Pentynoic acid

  • CAS No. 6089-09-4

  • Cat. No. CS-W008784
  • Purity≥98%
  • MDL No.MFCD00004407

*For research and further manufacturing use only, not for direct human use.

4-Pentynoic acid|CS-W008784

Structure of 6089-09-4

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General Information

  • CAS No. 6089-09-4
  • Cat. No. CS-W008784
  • Purity ≥98%
  • MDL No. MFCD00004407
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆O₂
  • Molecular Weight 98.10
  • Synonym(s) Propargylacetic acid
  • SMILES C#CCCC(O)=O

Description

4-Pentynoic acid undergoes copper-catalyzed intramolecular cyclizations to form enol lactones. It also reacts with 1-bromo-1-alkynes in the presence of a Pd catalyst to yield biologically active ynenol lactones.4-Pentynoic acid was used:as building block for the synthesis of library of eight sequence-defined model oligomersin one-pot synthesis of the complex polycyclic heterocycles benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinone derivativesin the synthesis of various allenenols lactones [5(E)-(2-allenylidene)-tetrahydro-2-furanones]in the synthesis of a cyctotoxic macrolide by ring-closing metathesis of a bis acetylene

Synthesis

  • Route1

    References

    • Abbiati, Giorgio; Contini, Alessandro; Nava, Donatella; Rossi, Elisabetta Tetrahedron, 2009 , vol. 65, # 24 p. 4664 - 4670
  • Route2

    References

    • Trost, Barry M.; Probst, Gary D.; Schoop, Andreas Journal of the American Chemical Society, 1998 , vol. 120, # 36 p. 9228 - 9236
  • Route3
    • null|null
      78181-02-9
    • ~66%
    • In-stock
      4-Pentynoic acid|CS-W008784
      6089-09-4

    References

    • Starostin; Ignatenko; Lapitskaya; Pivnitsky; Nikishin Russian Chemical Bulletin, 2001 , vol. 50, # 5 p. 833 - 837

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.4844
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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