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CS-W001157 4
Total: USD 88.00

2-Chloro-N-methyl-4-nitroaniline

  • CAS No. 6085-92-3

  • Cat. No. CS-0373798
  • Molecule weight186.60
  • Purity≥97%
  • MDL No.MFCD00130116

*For research and further manufacturing use only, not for direct human use.

2-Chloro-N-methyl-4-nitroaniline|CS-0373798

Structure of 6085-92-3

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General Information

  • CAS No. 6085-92-3
  • Cat. No. CS-0373798
  • Purity ≥97%
  • MDL No. MFCD00130116
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClN₂O₂
  • Molecular Weight 186.60
  • Synonym(s) 2-Chloro-4-Nitro-N-Methylaniline
  • SMILES O=[N+](C1=CC=C(NC)C(Cl)=C1)[O-]

Description

2-Chloro-N-methyl-4-nitroaniline features a chlorinated aromatic ring paired with a methylated aniline and a nitro group at the para position, enabling efficient coupling in cross-coupling reactions. The electron-deficient aryl chloride integrates readily into pharmaceutical intermediates and functional materials under standard conditions.

Application

2-Chloro-N-methyl-4-nitroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct introduction of both chloro and nitro functionalities adjacent to a methylamino group. Its reactivity facilitates nucleophilic aromatic substitution and subsequent coupling reactions, supporting the construction of complex heterocyclic scaffolds. Bench-stable and readily purified by crystallization, it offers reliable functional group tolerance in multi-step synthetic sequences.

Synthesis

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    • In-stock
      2-Chloro-N-methyl-4-nitroaniline|CS-0373798
      6085-92-3

    References

    • van Duin Recueil des Travaux Chimiques des Pays-Bas, 1932 , vol. 51, p. 878,879
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    • In-stock
      2-Chloro-N-methyl-4-nitroaniline|CS-0373798
      6085-92-3

    References

    • Stoermer; Hoffmann Chemische Berichte, 1898 , vol. 31, p. 2535
  • Route3

    References

    • Stoermer; Hoffmann Chemische Berichte, 1898 , vol. 31, p. 2535

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.17
  • LogP   2.2899
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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