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CS-W001157 4
Total: USD 88.00

N-Hydroxysuccinimide

  • CAS No. 6066-82-6

  • Cat. No. CS-W008598
  • Purity≥98%
  • MDL No.MFCD00005516

*For research and further manufacturing use only, not for direct human use.

N-Hydroxysuccinimide|CS-W008598

Structure of 6066-82-6

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General Information

  • CAS No. 6066-82-6
  • Cat. No. CS-W008598
  • Purity ≥98%
  • MDL No. MFCD00005516
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅NO₃
  • Molecular Weight 115.09
  • Synonym(s) HOSu; 1-Hydroxy-2,5-pyrrolidinedione
  • SMILES O=C(N1O)CCC1=O

Description

N-Hydroxysuccinimide serves as a pivotal reagent in conjugation chemistry, enabling efficient coupling of carboxyl groups to primary amines. This bench-stable compound features a reactive hydroxyl group adjacent to an electron-deficient imide ring, facilitating rapid amide bond formation under physiological conditions. Its utility spans bioconjugation, peptide synthesis, and the development of antibody-drug conjugates.

Synthesis

  • Route1

    References

    • EP1757583 A1, ; Page/Page column 14 ;
  • Route2
    • null|null
      41839-96-7
    • ~95%
    • In-stock
      N-Hydroxysuccinimide|CS-W008598
      6066-82-6

    References

    • Synthetic Communications, , vol. 31, # 5 p. 741 - 748
  • Route3

    References

    • EP1862442 A1, ; Page/Page column 16 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H318
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   57.61
  • LogP   -0.4754
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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