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CS-W001157 4
Total: USD 88.00

3-Hydroxy-5-methylbenzaldehyde

  • CAS No. 60549-26-0

  • Cat. No. CS-0153252
  • Purity≥98%
  • MDL No.MFCD16999707

*For research and further manufacturing use only, not for direct human use.

3-Hydroxy-5-methylbenzaldehyde|CS-0153252

Structure of 60549-26-0

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General Information

  • CAS No. 60549-26-0
  • Cat. No. CS-0153252
  • Purity ≥98%
  • MDL No. MFCD16999707
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈O₂
  • Molecular Weight 136.15
  • Synonym(s) None
  • SMILES CC1=CC(=CC(=C1)O)C=O

Description

3-Hydroxy-5-methylbenzaldehyde features a phenolic hydroxyl group flanked by a methyl substituent and an aldehyde functionality, enabling direct participation in electrophilic coupling reactions. This electron-rich scaffold supports efficient derivatization under mild conditions, delivering access to functionalized aromatic intermediates for medicinal chemistry and materials synthesis.

Application

3-Hydroxy-5-methylbenzaldehyde serves as a versatile building block in synthetic organic chemistry, enabling access to substituted benzene scaffolds via standard functional group transformations. Its ortho-hydroxyl and meta-methyl groups provide directional control in electrophilic substitution and facilitate regioselective derivatization. The aldehyde functionality supports nucleophilic addition, condensation reactions, and oxidation/reduction sequences, making it valuable for constructing heterocyclic intermediates and pharmaceutical precursors under routine laboratory conditions.

Synthesis

  • Route1

    References

    • Tibrewal, Nidhi; Downey, Theresa E.; Van Lanen, Steven G.; Ul Sharif, Ehesan; O'Doherty, George A.; Rohr, Juergen Journal of the American Chemical Society, 2012 , vol. 134, # 30 p. 12402 - 12405
  • Route2

    References

    • Tibrewal, Nidhi; Downey, Theresa E.; Van Lanen, Steven G.; Ul Sharif, Ehesan; O'Doherty, George A.; Rohr, Juergen Journal of the American Chemical Society, 2012 , vol. 134, # 30 p. 12402 - 12405
  • Route3
    • (3-Methoxy-5-methylphenyl)methanol|CS-0153249
      119650-44-1
    • ~%
    • In-stock
      3-Hydroxy-5-methylbenzaldehyde|CS-0153252
      60549-26-0

    References

    • Tibrewal, Nidhi; Downey, Theresa E.; Van Lanen, Steven G.; Ul Sharif, Ehesan; O'Doherty, George A.; Rohr, Juergen Journal of the American Chemical Society, 2012 , vol. 134, # 30 p. 12402 - 12405

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.51312
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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