Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Chloro-1-(2,5-difluorophenyl)ethan-1-one

  • CAS No. 60468-36-2

  • Cat. No. CS-W021631
  • Purity≥98%
  • MDL No.MFCD04115827

*For research and further manufacturing use only, not for direct human use.

2-Chloro-1-(2,5-difluorophenyl)ethan-1-one|CS-W021631

Structure of 60468-36-2

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 60468-36-2
  • Cat. No. CS-W021631
  • Purity ≥98%
  • MDL No. MFCD04115827
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClF₂O
  • Molecular Weight 190.58
  • Synonym(s) 2-Chloro-2',5-difluoroacetophenone
  • SMILES FC1=CC=C(F)C(C(CCl)=O)=C1

Description

2-Chloro-1-(2,5-difluorophenyl)ethan-1-one features a fluorinated aromatic ring paired with a chloroacetyl group, delivering enhanced stability and tailored electronic properties. This configuration enables efficient integration into synthetic routes requiring electron-deficient ketones. The compound exhibits robust performance under standard bench conditions, facilitating reliable use in medicinal chemistry and process development workflows.

Application

2-Chloro-1-(2,5-difluorophenyl)ethan-1-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of chiral intermediates via nucleophilic addition. The ortho-difluoro substitution enhances metabolic stability and modulates electronic properties, while the α-chloroketone functionality facilitates subsequent transformations such as cyclizations, reductive couplings, and heterocycle formation. Bench-stable and compatible with standard purification methods, it functions reliably in multi-step syntheses of pharmaceutical candidates.

Synthesis

  • Route1
    • null|null
      540-36-3
    • null|null
      79-04-9
    • ~70%
    • In-stock
      2-Chloro-1-(2,5-difluorophenyl)ethan-1-one|CS-W021631
      60468-36-2

    References

    • Rosen, Jonathan; Steinhuebel, Dietrich; Palucki, Michael; Davies, Ian Organic Letters, 2007 , vol. 9, # 4 p. 667 - 669

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.3863
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 60468-36-2 sigma60468-36-2 manufacturer60468-36-2 price60468-36-2 structure60468-36-2 SDSbuy 60468-36-260468-36-2 supplier60468-36-2 uses60468-36-2 molecular weightprice of 60468-36-260468-36-2 chemical name formula of 60468-36-2
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label